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Withdrawal Interval (WDI) Recommendations

for sheep, taken from the FARAD Digests

WARNING!

Extra Label Use of this drug is permissible under AMDUCA only if such use is by or on the lawful written or oral order of a licensed veterinarian within the context of a valid veterinarian-client-patient relationship.


Below are the WDI recommendations for the various route and dosage combination(s) for extra-label administration of in sheep.
Drug Route Dosage Frequency Meat WDI Milk WDI
acepromazine IM up to 0.44 mg/kg single and multiple doses 7 days 48 hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
acepromazine Reference(s): Drugs approved for small ruminants
acepromazine
acepromazine IV up to 0.13 mg/kg single and multiple doses 7 days 48 hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
acepromazine Reference(s): Drugs approved for small ruminants
activated charcoal PO n.a. n.a. 0 days 0 days
activated charcoal Reference(s): Antidotes in food animal practice
atropine IV up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine IM up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine SC up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
detomidine IV up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
detomidine
detomidine IM up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
dimethyl sulfoxide (DMSO) TOP n.a. n.a. 4 days 96 hours
dimethyl sulfoxide (DMSO)
Warnings:
pharmaceutical grade DMSO only
dimethyl sulfoxide (DMSO) Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides
epinephrine IV n.a. multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine IM n.a. multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine SC n.a. multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
fenbendazole PO 5 mg/kg single dose 28 days
fenbendazole Reference(s): Extralabel drug use in small ruminants
florfenicol SC 40 mg/kg single dose 42 days  
florfenicol
Warnings:
Meat and Milk WDI are based on limited data and vets are still encouraged to contact FARAD for WDI each time they use ELDU in case new data is available.
florfenicol Reference(s): Extralabel drug use in small ruminants
florfenicol
florfenicol IM 20 mg/kg every 48 hours x 2 60 days 168 hours plus test1
florfenicol
Warnings:
Meat and Milk WDI are based on limited data and vets are still encouraged to contact FARAD for WDI each time they use ELDU in case new data is available.
florfenicol Reference(s): Extralabel drug use in small ruminants
florfenicol 1 Important! FARAD recommends testing the milk from treated animals to ensure it is free of residues of the parent drug and drug metabolites before it is marketed for human consumption.
flunixin meglumine IM 2.2 mg/kg single dose 15 days 96 hours
flunixin meglumine
Warnings:
Meat and Milk WDI are based on limited data and vets are still encouraged to contact FARAD for WDI each time they use ELDU in case new data is available.
flunixin meglumine Reference(s): Extralabel drug use in small ruminants
flunixin meglumine
flunixin meglumine IV 2.2 mg/kg single dose 10 days 72 hours
flunixin meglumine
Warnings:
Meat and Milk WDI are based on limited data and vets are still encouraged to contact FARAD for WDI each time they use ELDU in case new data is available.
flunixin meglumine Reference(s): Extralabel drug use in small ruminants
guaifenesin IV up to 100 mg/kg single and multiple doses 3 days 48 hours
guaifenesin Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine IM up to 10 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine
ketamine IV up to 2 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine Reference(s): Drugs approved for small ruminants
lidocaine w/epinephrine INF n.a. single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
lidocaine w/epinephrine
lidocaine w/epinephrine EPI n.a. single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
meloxicam PO 1 mg/kg single dose 15 days  
meloxicam
Warnings:
Meat and Milk WDI are based on limited data and vets are still encouraged to contact FARAD for WDI each time they use ELDU in case new data is available.
meloxicam Reference(s): Extralabel drug use in small ruminants
oxytetracycline (long-acting) SC 20 mg/kg single dose 35 days 144 hours plus test1
oxytetracycline (long-acting)
Warnings:
Meat and Milk WDI are based on limited data and vets are still encouraged to contact FARAD for WDI each time they use ELDU in case new data is available.
oxytetracycline (long-acting) Reference(s): Extralabel drug use in small ruminants
oxytetracycline (long-acting) 1 Important! FARAD recommends testing the milk from treated animals to ensure it is free of residues of the parent drug and drug metabolites before it is marketed for human consumption.
pralidoxime (2-PAM) IM up to 30 mg/kg every 8 hours 28 days 6 days
pralidoxime (2-PAM)
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
pralidoxime (2-PAM) Reference(s): Antidotes in food animal practice
tetracyclines Top (Topical) n.a. n.a. 0 days 0 days
tetracyclines
Warnings:
provided there is no oral ingestion
tetracyclines Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides
thiopental IV up to 5 mg/kg n.a. 1 day 24 hours
thiopental Reference(s): Drugs approved for small ruminants
vitamin K1 (phytonadione) IV 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) IM 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) SC 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
xylazine IM 0.05 - 0.3 mg/kg single and multiple doses 4 days 24 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine
xylazine IM 0.3 - 2.0 mg/kg single and multiple doses 10 days 120 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine
xylazine IV 0.016 - 0.1 mg/kg single and multiple doses 5 days 72 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine Reference(s): Drugs approved for small ruminants
yohimbine IV up to 0.3 mg/kg single and multiple doses 7 days 72 hours
yohimbine Reference(s): Extralabel use of tranquilizers and general anesthetics


If you have further questions or concerns, please contact our ELDU advice team.
Sheep photo by Mark Hoffenberg