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Withdrawal Interval (WDI) Recommendations

WARNING!

Extra Label Use of this drug is permissible under AMDUCA only if such use is by or on the lawful written or oral order of a licensed veterinarian within the context of a valid veterinarian-client-patient relationship.


Below are the WDI recommendations for the various route and dosage combination(s) for extra-label administration of in cattle.

 

Drug Route Dosage Frequency Meat WDI Milk WDI
acepromazine IM up to 0.44mg/kg single and multiple doses 7 days 48 hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
acepromazine
acepromazine IV(Intravenous) upto 0.13 mg/kg single and multiple doses 7days 48hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
activated charcoal PO(Oral) not applicable not applicable 0 days 0 days
activated charcoal Reference(s): Antidotes in food animal practice
atropine IV up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine IM up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine SC up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
detomidine IV up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
detomidine
detomidine IM up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
dimethyl sulfoxide (DMSO) Topical not applicable not applicable 4 days 96 hours
dimethyl sulfoxide (DMSO)
Warnings:
pharmaceutical grade DMSO only
dimethyl sulfoxide (DMSO) Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides
epinephrine IV not applicable multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine IM not applicable multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine SC not applicable multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
florfenicol IMM 20 mg/kg single dose 28 days 120 hours and test with Charm II assay
florfenicol
Warnings:
systemic absorption post IMM infusion occurs
florfenicol Reference(s): Extralabel intramammary use of drugs in dairy cattle
flunixin meglumine IM up to 2.2 mg/kg single dose 30 days 72 hours
flunixin meglumine
Warnings:
ELDU for ease of drug administration is not allowed under AMDUCA. For flunixin, IM injection prolongs the WDI from 4 days (IV) to more than 30 days. Violative residues have been detected with IM flunixin administration and testing is strongly advised.
flunixin meglumine Reference(s): Extralabel use of nonsteroidal anti-inflammatory drugs in cattle
gentamicin IV up to 5 mg/kg every 24 hours for 10 days 18 months 5 days
gentamicin
Warnings:
test milk before returning to the milking string
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin IM up to 5 mg/kg every 24 hours for 10 days 18 months 5 days
gentamicin
Warnings:
test milk before returning to the milking string
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin SC up to 5 mg/kg every 24 hours for 10 days 18 months 5 days
gentamicin
Warnings:
test milk before returning to the milking string
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin IV not applicable not applicable 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin IM not applicable not applicable 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin SC not applicable not applicable 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin PO not applicable not applicable 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin Top not applicable not applicable 1 day  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin IMM 500 mg/quarter not applicable 180 days at least 10 days
gentamicin
Warnings:
FARAD strongly discourages intramammary administration of gentamicin in dairy cattle. Veterinarians are cautioned that the intramammary use of gentamicin is likely to be associated with prolonged tissue residues in cattle.
gentamicin Reference(s): Extralabel intramammary use of drugs in dairy cattle
guaifenesin IV up to 100 mg/kg single and multiple doses 3 days 48 hours
guaifenesin Reference(s): Extralabel use of tranquilizers and general anesthetics
ivermectin PO 0.2 mg/kg single dose 24 days 28 days
ivermectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
ivermectin
ivermectin SC 0.2 mg/kg single dose 35 days 47 days
ivermectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
ivermectin
ivermectin Top 0.5 mg/kg single dose 48 days 53 days
ivermectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
ketamine IM up to 10 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine
ketamine IV up to 2 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine
ketamine IV 5 mg/kg single and multiple doses Contact Farad 48 hours
ketamine Reference(s): Pharmacokinetics of ketamine in plasma and milk of mature Holstein cows
lidocaine w/epinephrine Infiltration not applicable single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
lidocaine w/epinephrine
lidocaine w/epinephrine Epidural not applicable single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
oxytetracycline (long-acting) IM 20 - 40 mg/kg single dose 50 days  
oxytetracycline (long-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (long-acting)
oxytetracycline (long-acting) IV 20 - 30 mg/kg single dose 192 hours  
oxytetracycline (long-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (long-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (long-acting)
oxytetracycline (long-acting) IM 20 - 30 mg/kg single dose 192 hours  
oxytetracycline (long-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (long-acting) Reference(s): Extralabel use of oxytetracycline
moxidectin SC 0.2 mg/kg single dose 49 days Not Available
moxidectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
moxidectin
moxidectin Top 0.5 mg/kg single dose 0 days 0 days
moxidectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
oxytetracycline IMM 426 mg every 12-24 hours for 1-3 doses 19 days 96 hours and test
oxytetracycline
Warnings:
diffuses into untreated quarters
oxytetracycline Reference(s): Extralabel use of oxytetracycline
oxytetracycline
oxytetracycline IMM 850 mg every 12-24 hours for 1-3 doses 19 days 120 hours and test
oxytetracycline
Warnings:
diffuses into untreated quarters
oxytetracycline Reference(s): Extralabel use of oxytetracycline
oxytetracycline
oxytetracycline IMM 500 mg/quarter not applicable 28 days 6 days
oxytetracycline
Warnings:
drug penetrates untreated quarters, therefore all milk should be discarded (not just treated quarter)
oxytetracycline Reference(s): Extralabel intramammary use of drugs in dairy cattle
oxytetracycline
oxytetracycline IU (Intrauterine) up to 2 g single dose 28 days 72 hours and test
oxytetracycline
Warnings:
only aqueous formulations of oxytetracycline and test as there is interindividual variability in residue elimination
oxytetracycline Reference(s): Update on FARAD food animal drug withholding recommendations
oxytetracycline
oxytetracycline IU (Intrauterine) 4 - 6 g single dose 35 days 192 hours and test
oxytetracycline Reference(s): Extralabel use of oxytetracycline
procaine penicillin g IU (Intrauterine) up to 2 million units not applicable 14 days  
procaine penicillin g
Warnings:
for larger doses, test milk and urine before adding to bulk tank or slaughtering
procaine penicillin g Reference(s): Extralabel use of penicillin in food animals
procaine penicillin g
procaine penicillin g Subconjunctival up to 300,000 units not applicable 12 days  
procaine penicillin g Reference(s): Extralabel use of penicillin in food animals
procaine penicillin g
procaine penicillin g IM 24,000 units/kg every 24 hours for 5 days 14 days  
procaine penicillin g
Warnings:
injection volume must not exceed 10 mls at one site
procaine penicillin g Reference(s): Extralabel use of penicillin in food animals
procaine penicillin g
procaine penicillin g IM 24,001 - 66,000 units/kg every 24 hours for 5 days 21 days  
procaine penicillin g
Warnings:
injection volume must not exceed 10 mls at one site
procaine penicillin g Reference(s): Extralabel use of penicillin in food animals
procaine penicillin g
procaine penicillin g IM up to 28,000 units/kg every 24 hours for 5 days   5 days
procaine penicillin g
Warnings:
based on a study where injection volume did not exceed 20 mls
procaine penicillin g Reference(s): Extralabel use of penicillin in food animals
povidone-iodine IMM not applicable not applicable   Not Applicable
povidone-iodine
Warnings:
for cessation of lactation, more effective than chlorhexidene, do not milk treated quarter
povidone-iodine Reference(s): Extralabel intramammary use of drugs in dairy cattle
pralidoxime (2-PAM) IM up to 30 mg/kg every 8 hours 28 days 6 days
pralidoxime (2-PAM)
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
pralidoxime (2-PAM) Reference(s): Antidotes in food animal practice
oxytetracycline (short-acting) IV 10 - 20 mg/kg up to 4 doses   144 hours
oxytetracycline (short-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IM 10 - 20 mg/kg up to 4 doses   144 hours
oxytetracycline (short-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IV greater than 20 mg/kg up to 4 doses every 24 hours 35 days  
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IM greater than 20 mg/kg up to 4 doses every 24 hours 35 days  
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting) IV 6.6 - 11 mg/kg intervals less than every 24 hours 28 to 30 days    
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IM 6.6 - 11 mg/kg intervals less than every 24 hours 28 to 30 days  
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
tetracyclines Top not applicable not applicable 1 day 24 hours
tetracyclines
Warnings:
provided there is no oral ingestion
tetracyclines Reference(s): Residue avoidance after Top application of veterinary drugs and parasiticides
tolazoline IV 2 - 4 mg/kg single dose 8 days 48 hours
tolazoline Reference(s): Update on FARAD food animal drug withholding recommendations
vitamin K1 (phytonadione) IV 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) IM 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) SC 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
xylazine IM 0.05 - 0.3 mg/kg single and multiple doses 4 days 24 hours
xylazine Reference(s): Update on FARAD food animal drug withholding recommendations
xylazine
xylazine IM 0.3 - 2.0 mg/kg single and multiple doses 10 days 120 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine
xylazine IV 0.016 - 0.1 mg/kg single and multiple doses 5 days 72 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
yohimbine IV up to 0.3 mg/kg single and multiple doses 7 days 72 hours
yohimbine Reference(s): Extralabel use of tranquilizers and general anesthetics
lidocaine Epidural up to 15 mL of 2% solution single and multiple doses 1 day 24 hours
lidocaine Reference(s): Pharmacokinetics of lidocaine in serum and milk of mature Holstein cows
lidocaine
lidocaine Infiltration up to 2 g in 100 mL single administration (inverted L block) 4 days 72 hours
lidocaine Reference(s): Pharmacokinetics of lidocaine in serum and milk of mature Holstein cows


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