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Withdrawal Interval (WDI) Recommendations

WARNING!

Extra Label Use of this drug is permissible under AMDUCA only if such use is by or on the lawful written or oral order of a licensed veterinarian within the context of a valid veterinarian-client-patient relationship.


Below are the WDI recommendations for the various route and dosage combination(s) for extra-label administration of in sheep.
Drug Route Dosage Frequency Meat WDI Milk WDI
acepromazine IM up to 0.44 mg/kg single and multiple doses 7 days 48 hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
acepromazine Reference(s): Drugs approved for small ruminants
acepromazine
acepromazine IV up to 0.13 mg/kg single and multiple doses 7 days 48 hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
acepromazine Reference(s): Drugs approved for small ruminants
activated charcoal PO not applicable not applicable 0 days 0 days
activated charcoal Reference(s): Antidotes in food animal practice
atropine IV up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine IM up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine SC up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
detomidine IV up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
detomidine
detomidine IM up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
dimethyl sulfoxide (DMSO) Topical not applicable not applicable 4 days 96 hours
dimethyl sulfoxide (DMSO)
Warnings:
pharmaceutical grade DMSO only
dimethyl sulfoxide (DMSO) Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides
epinephrine IV not applicable multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine IM not applicable multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine SC not applicable multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
guaifenesin IV up to 100 mg/kg single and multiple doses 3 days 48 hours
guaifenesin Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine IM up to 10 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine
ketamine IV up to 2 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine Reference(s): Drugs approved for small ruminants
lidocaine w/epinephrine Infiltration not applicable single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
lidocaine w/epinephrine
lidocaine w/epinephrine Epidural not applicable single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
pralidoxime (2-PAM) IM up to 30 mg/kg every 8 hours 28 days 6 days
pralidoxime (2-PAM)
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
pralidoxime (2-PAM) Reference(s): Antidotes in food animal practice
tetracyclines Top not applicable not applicable 0 days 0 days
tetracyclines
Warnings:
provided there is no oral ingestion
tetracyclines Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides
thiopental IV up to 5 mg/kg not applicable 1 day 24 hours
thiopental Reference(s): Drugs approved for small ruminants
vitamin K1 (phytonadione) IV 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) IM 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) SC 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
xylazine IM 0.05 - 0.3 mg/kg single and multiple doses 4 days 24 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine
xylazine IM 0.3 - 2.0 mg/kg single and multiple doses 10 days 120 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine
xylazine IV 0.016 - 0.1 mg/kg single and multiple doses 5 days 72 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine Reference(s): Drugs approved for small ruminants
yohimbine IV up to 0.3 mg/kg single and multiple doses 7 days 72 hours
yohimbine Reference(s): Extralabel use of tranquilizers and general anesthetics


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Sheep photo by Mark Hoffenberg